Some thoughts from a speech by Neil Gaiman:

Ignore all advice.

In my experience, most interesting art gets made by people who don’t know the rules, and have no idea that certain things simply aren’t done: so they do them. Transgress. Break things. Have too much fun.

Another piece of advice:

I’ve learned over the years that everything is more or less the same amount of work, so you may as well set your sights high and try and do something really cool.